Welcome to taPrime Consulting
taprime provides consultancy services, solving freeze drying problems, helping you develop robust formulations and processes, and providing expert advice to the pharmaceutical and life sciences industries. We believe that freeze drying is a science and not an art, even though it may not follow text book chemistry. Text book chemistry primarily describes systems that are in thermodynamic equilibrium, but in general a frozen solution is not, it is under kinetic control. This is the key to understanding freeze drying and leads us towards rational process and product design, and away from trial and error experimentation. Follow the link for more details of our services.
What is the freezing point of water?
Have you ever wondered why water never freezes at its freezing point, or why your vials all freeze at different times and temperatures? Perhaps even why your DSC samples freeze at lower temperatures than the same solution in a vial? Although we often talk about the freezing point of water, in fact, water does not have a unique and reproducible freezing point. Interested in knowing more, then download our latest taPrimer the physics of freezing.
Other articles on the science of freeze drying can be found in our taPrimer archive.
Looking for information about freeze drying?
It isn't always easy to find the information you want, but this web site can help in two ways. On our Useful Information page we have collected some information on basic physical properties, Tg' values, SVP of water over ice at various temperatures, and a conversion table for various pressure units. From time to time we also publish some tutorial articles on different aspects of freeze-drying; these are our taPrimers. Newly published articles are featured on our home page, but we also maintain an archive of all our tutorials in our taPrimer archive.
We now offer a 2 day in house training course. Click here for more details.
Interested in the development of Gene Based Drugs? The BioUpdate Foundation is running a 2 day course in Amersfoort, The Netherlands, October 29-30, 2012.
